Plain-English translation of NCT06595355 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This trial is testing whether combining bevacizumab (an eye injection) with curcumin (an oral supplement made from turmeric) works better than the injection alone for treating diabetic macular edema—a type of eye swelling caused by diabetes that can affect your vision. Half of the participants will receive the injection plus curcumin pills, while the other half will receive the injection plus placebo (dummy) pills. Researchers will measure whether the medication helps reduce the swelling in your retina and improve how well you can see.
Diabetic macular edema is a serious complication that can lead to vision loss. While the injection bevacizumab helps many people, doctors want to know if adding curcumin—a natural substance with anti-inflammatory properties—might make the treatment even more effective at reducing swelling and protecting your vision.
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You will receive an intravitreal injection of bevacizumab (delivered directly into your eye) as the standard treatment. You will also take daily oral pills—either containing curcumin or placebo—depending on which group you are randomly assigned to. Throughout the study, you will have several follow-up visits where doctors will measure the thickness and swelling of your macula using imaging tests (OCT scans) and check your vision to see how well the treatment is working.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
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