Recruiting

Adding beneficial bacteria to standard care for ulcerative colitis

Plain-English translation of NCT06595719 on ClinicalTrials.gov ↗ · Source last updated March 2025 · Translation generated June 2026 · How we translate trials

Read our Ulcerative Colitis research guide →

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing a multi-strain probiotic supplement — a combination of beneficial bacteria from the Bifidobacterium and Lactobacillus families — added to your regular ulcerative colitis care. The study will compare people who receive the medication with those who receive a placebo (inactive pill) over 12 weeks. Researchers want to see if this treatment can help restore the balance of bacteria in your gut, strengthen your intestinal lining, and reduce inflammation.

Many people with mild to moderate ulcerative colitis continue to have symptoms or side effects even with current treatments. Recent research suggests that an imbalance in gut bacteria plays a role in ulcerative colitis, so this study is exploring whether restoring that balance with this medication might help patients feel better and achieve longer-lasting improvement.

Do you qualify?

You likely qualify if…

you have been diagnosed with ulcerative colitis confirmed by colonoscopy and tissue biopsy
your ulcerative colitis affects at least the lower portion of your colon (rectosigmoid region), confirmed by colonoscopy at the start of the study
your disease is mild to moderate in severity at the time of enrollment
you have been taking your regular ulcerative colitis medications consistently for at least 4 weeks before starting the trial

You likely don't qualify if…

you have Crohn's disease or pouchitis instead of ulcerative colitis
your ulcerative colitis is severe at the time of screening
you have taken antibiotics in the 2 weeks before the study starts
you have changed the dose of your ulcerative colitis medications in the past 4 weeks
you have taken any probiotic supplements (prescription or over-the-counter) in the 2 weeks before the study

What participation looks like

If you join this trial, you will take either the probiotic supplement or a placebo pill daily for 12 weeks, while continuing your regular ulcerative colitis medications at the same dose. You will need to keep taking your standard medications unchanged throughout the study and avoid certain other medications like NSAIDs and antibiotics during this time. The study will likely include visits where your symptoms are checked, and possibly tests or procedures to measure how well your intestines are healing.

AI-generated summary from trial data · Jun 2, 2026 · Not medical advice

Trial locations(1 site)

Malaysia

Hospital Canselor Tuanku Muhriz UKM, Cheras, Kuala Lumpur