Plain-English translation of NCT06600178 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This trial is testing a medication called Brezavvy to see if it can help women with a specific heart condition where tiny blood vessels in the heart aren't working well, causing chest pain and reduced blood flow. Even though the main arteries of the heart are normal, these smaller vessels struggle to deliver enough blood during stress or activity. The study will compare women taking Brezavvy to those taking a placebo (inactive pill) to see if the medication improves blood flow and reduces symptoms.
Many women experience chest pain and heart-related symptoms, but their main heart arteries look normal on standard tests—this condition is called microvascular disease. Current treatments don't work well for everyone, so researchers are testing this medication to see if it can help improve how these tiny blood vessels function and relieve symptoms.
You likely qualify if…
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You will be randomly assigned to take either Brezavvy or a placebo pill by mouth daily. You'll attend study visits where your heart function will be monitored using imaging tests (like heart scans) and blood work. The study will track whether the medication improves your blood flow and reduces your chest pain symptoms over time. Your doctors will check that the medication is safe and working well for you throughout the trial.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
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