Plain-English translation of NCT06604273 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
Researchers are studying how scar tissue develops in the intestines of people with ulcerative colitis who are being treated with filgotinib. This trial uses special imaging scans to detect and track scar tissue formation over time. The goal is to better understand which patients are at risk for scarring and how this new medication affects the scarring process.
Scar tissue in the intestines can cause serious complications for people with ulcerative colitis, but doctors don't yet have good tools to detect it early or understand what causes it. This study aims to fill that gap by using advanced imaging to monitor scarring and identify the biological processes involved.
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All participants will start taking filgotinib for their ulcerative colitis. Some participants will also undergo a special imaging scan called FAPi-PET/CT, which takes pictures to detect scar tissue in the intestines. The study involves hospital visits for blood tests, imaging, and medical exams to track how the medication works and monitor for intestinal scarring.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
Netherlands
Phase
Large-scale testing
Sponsor
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Enrollment target
~10 participants
Started
April 2024
Primary completion
October 2025
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years and older
Last updated on clinicaltrials.gov in September 2024.
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Central contact
Dalia A Lartey, MD
Amsterdam UMC, location VUmc
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