Blood and tissue collection study to develop better cancer detection tests

Plain-English translation of NCT06605404 on ClinicalTrials.gov ↗ · Source last updated August 2025 · Translation generated June 2026 · How we translate trials

What is this trial?

This is an observational study—meaning researchers will follow your care without testing a new medication, but instead will collect your blood and tumor tissue samples over about 5.5 years. The goal is to develop new blood tests that can detect cancer earlier and help doctors understand which patients are at higher risk for cancer returning after treatment.

Currently, doctors don't have reliable blood tests to detect whether tiny amounts of cancer remain in a patient's body after surgery and treatment. This study aims to create better tools to catch cancer recurrence earlier, when it's easier to treat.

Do you qualify?

You likely qualify if…

you are 18 years or older
you have been newly diagnosed with one of the included solid cancers (bladder, esophageal, stomach, melanoma, lung, pancreatic, or other eligible tumors) at stage I, II, or operable stage III
you are scheduled for or have recently had surgery to remove your cancer (within 3 months of surgery)
you have not yet received chemotherapy or other systemic cancer treatment for this diagnosis
you are in good enough health to participate (ECOG performance status 0, 1, or 2)
you have not had another cancer diagnosis in the past 3 years (except non-melanoma skin cancers)

You likely don't qualify if…

you have been diagnosed with brain or spinal cord cancer, colorectal cancer, breast cancer, thyroid cancer, or blood cancers such as lymphoma or leukemia
you have already started chemotherapy or other systemic treatment for your current cancer
you have had a previous cancer in the past 3 years that required treatment
you have had a stem cell or bone marrow transplant in the past
you currently have another active invasive cancer at the same time

What participation looks like

You will continue to receive your normal cancer care from your doctor. In addition, you will have blood drawn several times over the study period and provide your tumor tissue sample (which is usually collected during your surgery or diagnostic biopsy). Your participation is expected to last about 5.5 years, during which researchers will follow your health outcomes and use your samples to develop and test new cancer detection blood tests.

AI-generated summary from trial data · Jun 9, 2026 · Not medical advice

Trial locations(2 sites)

United States

Medical Oncology Associates of San Diego, San Diego, California

Taylor Cancer Research Center, Maumee, Ohio