Plain-English translation of NCT06606327 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
Researchers are testing whether diazoxide, an oral medication, can help lower insulin levels in people with obesity. The goal is to understand whether some people's high insulin levels are a primary problem that actually causes insulin resistance, rather than just a side effect of it. This study will help validate a new, simpler outpatient test compared to a more complex procedure currently used in research.
Scientists have long wondered whether high insulin levels in people with obesity are the root cause of their metabolic problems, or simply their body's attempt to compensate for insulin resistance. This medication offers a way to lower insulin levels independently, which would help answer that question and could lead to better treatments.
You likely qualify if…
You likely don't qualify if…
If you qualify, you will take diazoxide oral suspension by mouth for 4 days, receiving 8 doses total (one dose roughly every 12 hours). The study team will monitor your blood glucose and insulin levels before, during, and after treatment to see how your body responds. You must have already completed the initial screening test (GIST) to participate, and the researchers will compare your results from this simpler outpatient medication test to that screening.
AI-generated summary from trial data · Jun 4, 2026 · Not medical advice
United States
Phase
Safety & dosing
Sponsor
Columbia University
Collaborators
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), University of Pisa
Enrollment target
~10 participants
Started
October 2024
Primary completion
November 2027
Age range
18 Years – 65 Years
Last updated on clinicaltrials.gov in December 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Joshua R Cook, MD, PhD
Columbia University
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.