Plain-English translation of NCT06608277 on ClinicalTrials.gov ↗ · Source last updated · Translation generated ·
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This study is testing whether two treatments—a nerve block injection (called a stellate ganglion block) and an infusion of ketamine—can help reduce headaches and post-traumatic stress symptoms that develop after a traumatic brain injury. Right now, there are no proven, reliable treatments for these conditions, so researchers want to see if one or both of these approaches might work better than a placebo (a fake treatment).
Many people who suffer traumatic brain injuries develop long-lasting headaches and PTSD symptoms, but current treatments don't work well for everyone. Early research suggests that both the nerve block and ketamine infusion might help, but we need a careful study to find out if they really do and which one (or combination) works best.
You likely qualify if…
You likely don't qualify if…
You will be randomly assigned to receive one of four treatments: the nerve block with placebo infusion, the placebo block with ketamine infusion, both the real nerve block and real ketamine infusion, or both placebos (fake versions). You'll have the procedure(s) done during an initial visit, then complete questionnaires about your symptoms at 1, 2, and 4 weeks. If your symptoms improve at 4 weeks, you'll continue with follow-up visits at 8, 12 weeks, and 6 months. If you don't improve, you'll exit the study but can receive other treatments recommended by your doctor.
AI-generated summary from trial data · Jun 11, 2026 · Not medical advice
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