Plain-English translation of NCT06609356 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Type 1 Diabetes Mellitus research guide →Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
Researchers want to understand whether using an SGLT2 inhibitor—a medication that helps your body remove sugar through urine—can reduce how much insulin people with type 1 diabetes need to take. When you take less insulin, your body may have better heart and blood vessel health. This study will test your heart function and insulin sensitivity under two different insulin conditions to see if lower insulin levels make a real difference.
People with type 1 diabetes often need to take high doses of insulin, which may stress the heart and blood vessels over time. Researchers believe that if they can safely lower insulin requirements using this medication, it could protect heart health and improve how well insulin works in the body.
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You will visit the research center for testing sessions where researchers will measure your heart and blood vessel function. During the visits, you will receive two different insulin infusions on separate occasions—one that mimics high insulin levels typical of type 1 diabetes, and another with normal insulin levels—so the team can compare how your body responds. The study involves blood tests and non-invasive measurements of heart health, and the entire participation typically takes place over a few weeks.
AI-generated summary from trial data · Jun 22, 2026 · Not medical advice
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