Testing a New Medication to Reduce Pain Crises in Sickle Cell Disease

This is a global study testing whether a new medication called etavopivat can help reduce vaso-occlusive crises — the severe pain events that happen when sickle cells block blood vessels — in people with sickle cell disease. The medication is also being studied to see if it can reduce organ damage, improve how far you can exercise, and decrease fatigue. You'd have a 50/50 chance of receiving either the medication or a placebo (a pill with no active ingredient), and the study lasts about 2 years.

Sickle cell disease causes unpredictable and debilitating pain crises that can damage organs and limit quality of life. This medication is being tested because early research suggests it may help prevent these crises and improve overall health in people living with this condition.