Plain-English translation of NCT06614309 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Researchers at Mayo Clinic are investigating whether brief exposures to different breathing conditions—including higher carbon dioxide levels and lower oxygen levels—might help reduce brain fog in people with Long COVID. The study will test these breathing interventions on a small group of 45 patients to see if they improve thinking and memory problems that linger after COVID-19.
Many people with Long COVID experience persistent brain fog that affects their ability to think clearly and remember things. Current treatments are limited, so this study explores whether controlled breathing exercises might offer a new way to help ease these symptoms.
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You would visit the study site multiple times to receive three different breathing interventions in a specific order—one will be a placebo (inactive control), and two will involve controlled breathing exercises with different oxygen and carbon dioxide levels. The order in which you receive each intervention will be randomly assigned. Researchers will measure your brain blood flow and cognitive symptoms before, during, and after each intervention to see if the breathing exercises help reduce your brain fog.
AI-generated summary from trial data · Jun 20, 2026 · Not medical advice
United States
Sponsor
Mayo Clinic
Enrollment target
~45 participants
Started
September 2024
Primary completion
December 2026
Age range
18 Years and older
Last updated on clinicaltrials.gov in June 2026.
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Central contact
Jordan Parks
Mayo Clinic
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.