Testing if nerve sensitivity exams predict which pain medications work best

Plain-English translation of NCT06614322 on ClinicalTrials.gov ↗ · Source last updated April 2026 · Translation generated June 2026 · How we translate trials

Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.

What is this trial?

This trial is testing whether a bedside nerve sensitivity test can help doctors predict which pain medication will work best for you. You'll try three different treatments — , , and a placebo — over 19 weeks in a rotating pattern. The goal is to see if the nerve sensitivity test can identify which patients respond best to each medication.

Nerve pain in the feet can be difficult to treat, and different medications work better for different people. This study aims to find a simple test that can help doctors predict ahead of time which medication is most likely to help you personally, rather than relying on trial and error.

Do you qualify?

You likely qualify if…

you are between 18 and 80 years old
you have been diagnosed with nerve pain in both feet for at least 6 months
your average daily worst pain is rated between 4 and 9 on a 0-to-10 pain scale
you can read and understand English and complete surveys on a computer
you have been on stable pain medications or pain treatments for at least one month and are willing to keep them the same during the study

You likely don't qualify if…

you are currently taking opioid pain medications at high doses (more than 30 morphine equivalents per day)
you have a different type of foot pain that is worse than your nerve pain, such as arthritis or plantar fasciitis
you have nerve pain caused by a brain or spinal cord condition, such as Parkinson's disease or spinal cord injury
you have had surgery or a serious injury that directly caused your nerve pain

What participation looks like

You'll visit the clinic for a nerve sensitivity exam and blood draw, then take one of three medications (or placebo) for about 3 weeks, followed by a washout period, then switch to a different medication for another 3 weeks. This cycle happens three times over 19 weeks total. Throughout the study, you'll report your pain levels and how you're feeling using a simple online form from home. Researchers will compare how well each medication worked for you based on both your pain ratings and your own sense of improvement.

AI-generated summary from trial data · Jun 25, 2026 · Not medical advice

Testing if nerve sensitivity exams predict which pain medications work best

What is this trial?

Do you qualify?

What participation looks like

Trial locations(7 sites)