Testing short-term blood thinner after heart device placement for irregular heartbeat

This trial is testing a new approach for people with atrial fibrillation (irregular heartbeat) who have had a special closure device called the LAmbre device implanted in their heart. Instead of taking blood thinners for life, participants will take just one blood thinner medication — either aspirin or clopidogrel — for only three months after the device is placed. The study will follow 234 patients for one year to see if this shorter treatment is safe and works well.

People with irregular heartbeat often need long-term blood thinners to prevent stroke, but some patients cannot tolerate these medications due to bleeding risks or other health conditions. This trial is testing whether a special heart device combined with a much shorter course of a single blood thinner could be a safer option for these patients while still protecting them from stroke.