Plain-English translation of NCT06621394 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Depressive Disorder, Major research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether two lifestyle approaches—eating a Mediterranean diet and practicing mindful eating—can help reduce depression symptoms in people who are living with both obesity and major depression. The study will also explore whether combining both approaches works better than either one alone. You'll be placed into one of four groups: one receiving Mediterranean diet guidance, one learning mindful eating techniques, one receiving both, or a comparison group focused on friendly support visits.
Depression and obesity often occur together, and many people struggle to find effective treatments for both conditions. Research suggests that the Mediterranean diet may improve mental health, and changing how we eat—not just what we eat—might also help with depression. This trial aims to fill a gap in care by testing whether these two approaches can work together to reduce depression severity.
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If you join this study, you'll be randomly assigned to one of four groups for 12 weeks. During this time, you'll have five individual nutrition counseling meetings with a specialist to learn about your assigned approach (Mediterranean diet, mindful eating, both, or supportive befriending visits). After the 12-week intervention ends, you'll continue being followed for another 12 weeks. Throughout the study, you'll complete questionnaires about your mood, eating habits, quality of life, and overall well-being. Some participants will also provide a microbiome sample (a simple stool sample) to help researchers understand how diet may affect depression.
AI-generated summary from trial data · Jun 8, 2026 · Not medical advice
Germany