Recruiting

Testing a new cancer drug combined with other treatments for advanced tumors

Plain-English translation of NCT06621563 on ClinicalTrials.gov ↗ · Source last updated April 2025 · Translation generated August 2026 · How we translate trials

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Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.

What is this trial?

This trial is testing a new drug called HS-20117 that researchers believe may help fight advanced cancers when combined with other existing cancer medications. The study is looking at whether this medication is safe, well-tolerated, and effective for people with advanced lung cancer or colorectal cancer. Researchers want to find the right dose and understand how this treatment works in your body.

Some patients with advanced lung cancer or colorectal cancer don't respond well enough to current treatments, or their cancers come back after treatment. This trial is exploring whether combining this medication with other therapies might offer a better option for these patients.

Do you qualify?

You likely qualify if…

you are between 18 and 75 years old
you have been diagnosed with advanced lung cancer, colorectal cancer, or another advanced solid tumor that cannot be removed by surgery
you have good overall health and physical function, with a life expectancy of at least 12 weeks
you have at least one measurable tumor that can be tracked during the study
you are willing to use reliable contraception during the trial if you are able to become pregnant

You likely don't qualify if…

you have received certain cancer drugs targeting MET or EGFR in the past few weeks
you have had chemotherapy, targeted therapy, or other systemic cancer treatment within 2 weeks before starting the trial
you have had major surgery within 4 weeks, or radiation therapy affecting a large area of bone marrow within 4 weeks
you have active, untreated cancer that has spread to your brain, or fluid around your lungs or heart requiring medical drainage
you have a serious infection, severe heart problems, or ongoing side effects from previous cancer treatments

What participation looks like

You would visit the study clinic regularly for check-ups, blood tests, and imaging scans (like CT scans) to monitor your cancer and how you're responding to the medication. You would take the new medication by mouth, usually in combination with another cancer drug that your doctor prescribes. The trial has two parts: first, researchers find the safest and most effective dose, and then they expand the study to confirm how well the treatment works in a larger group of patients with specific types of cancer.

AI-generated summary from trial data · Aug 11, 2026 · Not medical advice

Trial locations(1 site)

China

Tianjin Medical University Cancer Institute & Hospital, Tianjin