Testing an antiparasitic drug combined with radiation for childhood brain tumors

This clinical trial is testing whether a medication called atovaquone can help treat certain aggressive brain tumors in children and young adults when combined with radiation therapy. Atovaquone is already an FDA-approved drug used to treat parasitic infections, so doctors know it's generally safe. The study explores whether this medication might work better than standard treatment alone by helping radiation therapy kill cancer cells more effectively.

Some childhood brain tumors are very hard to treat and don't respond well to standard therapies. This medication has shown promise in early research for slowing cancer growth and may be particularly effective for brain tumors because it can reach the brain easily. This trial aims to see if adding this treatment to radiation therapy can improve outcomes for children whose tumors have just been diagnosed or have come back after previous treatment.