Recruiting

New Stem Cell Treatment for Hard-to-Treat Solid Tumors in Young People

Plain-English translation of NCT06625190 on ClinicalTrials.gov ↗ · Source last updated June 2026 · Translation generated July 2026 · How we translate trials

Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.

What is this trial?

This trial is testing a new type of stem cell transplant for young people (ages 6 months to 25 years) whose solid tumors have stopped responding to standard chemotherapy. The transplant uses stem cells from a family member donor that have been specially processed in the lab, combined with , a medication that may help boost the immune system's ability to fight the cancer.

Many young people with certain solid tumors don't respond well to standard chemotherapy or traditional stem cell transplants. Researchers believe that using specially prepared donor stem cells combined with this medication may help the immune system recognize and attack cancer cells more effectively, potentially improving survival rates for these hard-to-treat cancers.

Do you qualify?

You likely qualify if…

you are between 6 months and 25 years old
you have been diagnosed with a relapsed or hard-to-treat solid tumor (such as neuroblastoma, rhabdomyosarcoma, Ewing sarcoma, or Wilms tumor) that has not responded to standard treatment
you have a family member (half-matched relative) who can be a stem cell donor
your heart, lungs, and kidneys are functioning well enough to tolerate the transplant
you are able to perform daily activities at a reasonable level despite your illness

You likely don't qualify if…

you have an active, uncontrolled infection at the time of enrollment
you have more than one active cancer at the same time
your heart, lung, or kidney function is severely compromised
you are pregnant or unwilling to use contraception during and for one year after the transplant

What participation looks like

You would receive chemotherapy to prepare your body for the transplant, then receive the specially treated stem cells from your donor family member. After the transplant, you will have frequent clinic visits for monitoring, blood tests, and imaging scans to check how well the transplant is working and to watch for side effects. The study team will follow you closely over months and years to see if this treatment helps control your cancer and improves your survival.

New Stem Cell Treatment for Hard-to-Treat Solid Tumors in Young People

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)