Receive radiation therapy and take medication to treat high-risk prostate cancer

Back to High Risk Prostate Carcinoma trials

Recruiting

What is this trial?

This trial is testing whether adding —a newer hormone-blocking medication—to standard prostate cancer treatment can help prevent cancer from spreading to other parts of your body. You'll also be randomly assigned to receive either traditional radiation therapy or a newer, more focused type called stereotactic radiation. The goal is to see if one or both of these approaches work better than standard treatment alone.

Men with high-risk prostate cancer have a significant chance of their cancer returning or spreading, even after treatment. Researchers want to know if this medication or the newer radiation technique—or both together—can reduce that risk and help men live longer without their cancer progressing.

Do you qualify?

You likely qualify if…

you are a man between 18 and 80 years old
you have been diagnosed with prostate cancer that has high-risk features (such as an aggressive appearance under the microscope, a large tumor, or a high PSA blood level)
you have not had prior prostate cancer treatment besides hormone therapy started more than 6 weeks ago
you are in good enough health to tolerate treatment and follow-up care for 2 years
you have normal blood counts, liver function, and kidney function

You likely don't qualify if…

you have evidence that your cancer has already spread to other parts of your body
you have had a TURP procedure or prostate removal surgery within the last 6 months
you have had other treatments for prostate cancer (besides certain hormone therapies started early)
you have serious heart disease, uncontrolled high blood pressure, or other severe medical conditions
you have active infection with HIV, hepatitis, or other serious infections

What participation looks like

You will be randomly assigned to one of four treatment groups. All groups receive hormone therapy and radiation to the pelvis; some groups also receive the new medication, and some receive a more focused radiation technique to the prostate. You'll visit the clinic at 6 weeks, 3 months, 6 months, then every 3 months for 2 years for checkups and blood tests to monitor PSA levels. After that, you'll have imaging scans if there are any signs of concern. The study tracks whether and when cancer spreads for several years.

Testing a new medication and advanced radiation therapy for high-risk prostate cancer

What is this trial?

Do you qualify?

What participation looks like

Trial locations(6 sites)