Plain-English translation of NCT06627270 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This study is testing whether and chlorhexidine rinse, given before surgery, can reduce the amount of bacteria inside oral cancer tumors. Researchers believe that bacteria living inside tumors may weaken the immune system's ability to fight cancer, and reducing these bacteria might help improve treatment outcomes.
Oral cancers that haven't been caused by HPV tend to have poor outcomes because the tumor environment suppresses the immune system. Recent research suggests that bacteria living inside tumors and gum disease may contribute to this immune suppression, so reducing bacteria before surgery could potentially unlock the immune system's ability to fight cancer.
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You would take pills three times daily and use a chlorhexidine rinse three times daily for 10 days before your scheduled cancer surgery. During these 10 days, researchers will monitor you to make sure the medications are tolerated well. When you have your surgery, the surgical team will collect tissue samples to study how much bacteria is present in the tumor and how your immune cells have changed.
AI-generated summary from trial data · Jun 7, 2026 · Not medical advice
United States