Plain-English translation of NCT06628154 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
Researchers want to understand how losartan, a medication that blocks a hormone system involved in blood pressure control, might also affect how your brain processes emotions and learns from emotional experiences. This brain hormone system is also found in areas of the brain linked to anxiety and depression, so scientists think losartan might help with emotional learning in ways that could be useful for treating anxiety and trauma-related disorders.
Some research suggests this medication might help people recover from traumatic stress and work better with antidepressants, but scientists don't fully understand how it works in the brain. This study aims to fill that gap by examining exactly how this treatment affects emotional processing in healthy people.
You likely qualify if…
You likely don't qualify if…
You will attend a screening visit where researchers will check your health and confirm you qualify. Then you'll return for the main study visit, where you'll take either the medication or a placebo (a dummy pill that looks identical), and complete computer-based tasks and questionnaires that test how you learn from and respond to emotional images or situations. The entire process involves a single dose of treatment, so you won't need to take medication repeatedly or over a long period.
AI-generated summary from trial data · Jul 8, 2026 · Not medical advice
United Kingdom
Phase
Safety & dosing
Sponsor
University of Oxford
Collaborators
National Institute for Health Research, United Kingdom
Enrollment target
~60 participants
Started
August 2024
Primary completion
July 2025
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years – 50 Years
Last updated on clinicaltrials.gov in October 2024.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Andrea Reinecke, PhD
University of Oxford
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.