Plain-English translation of NCT06630130 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether adding newer medications like (T-DXd), , , and to standard chemotherapy can help shrink stomach tumors before surgery and improve survival afterward. The study is divided into three treatment groups, each testing a different combination of these drugs. Researchers want to see which combination works best for people whose stomach cancer is too advanced to remove with surgery alone.
Stomach cancer that has spread to nearby tissues or lymph nodes is very hard to treat with surgery alone. This medication is being tested because early studies suggest these newer drugs, especially when combined together, may help shrink tumors more effectively and prevent the cancer from coming back after surgery.
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If you join, you will receive the study medication by IV infusion and take pills by mouth for three 3-week cycles before surgery. Then you will have surgery to remove the cancer. After recovery (4 to 12 weeks later), you will receive more of the medication for up to 12 months. Throughout the trial, you will have regular CT or MRI scans to measure how well the treatment is working—first before treatment starts, then after the initial medication cycles, after surgery, and then every 12 weeks for the first year and every 24 weeks after that.
AI-generated summary from trial data · Jul 4, 2026 · Not medical advice
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