Monthly injections to prevent overdose in people using stimulants

This trial is testing whether naltrexone, given as a monthly injection, can help prevent opioid overdose in people living with HIV or at risk for HIV who use stimulants like cocaine or methamphetamine. The medication blocks the effects of opioids, which can reduce the risk of overdose if someone is exposed to them. Researchers want to see if this approach is safe, acceptable to participants, and actually works.

Many people who use stimulants are also exposed to opioids, particularly fentanyl, which is a leading cause of overdose deaths. This medication has been used to treat opioid addiction, but researchers want to learn if it can be used as a preventive tool—like a shield—for people at high risk of accidental opioid exposure.