Plain-English translation of NCT06634069 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing two different intravenous fluids that doctors can give to critically ill patients with severe infection (septic shock). Researchers want to compare 0.5M against 3% saline solution to see which one is better at stabilizing blood pressure, improving blood flow to vital organs, and correcting dangerous changes in blood chemistry. Both fluids are already used in some ICUs, but this study will help doctors understand which one works better.
Severe infection can cause dangerous drops in blood pressure and organ damage if not treated quickly with the right fluids. Doctors need to know which of these two IV fluids is most effective at saving lives and protecting the brain and other organs in septic shock patients.
You likely qualify if…
You likely don't qualify if…
If you enroll, you'll be randomly assigned to receive one of the two IV fluids while you're in the intensive care unit. Doctors will closely monitor your blood pressure, heart function, blood chemistry, and organ function with standard ICU care including heart monitors and blood tests. The study team will compare how your body responds to the fluid you received versus how patients receiving the other fluid responded.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
Czechia
Phase
Testing effectiveness
Sponsor
University Hospital Pilsen
Enrollment target
~40 participants
Started
November 2024
Primary completion
October 2027
Age range
18 Years – 90 Years
Last updated on clinicaltrials.gov in April 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Miroslav Kříž, MD
University Hospital Pilsen
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.