Plain-English translation of NCT06634121 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Your heart has a valve called the mitral valve that can sometimes leak, causing blood to flow backward. This trial compares two FDA-approved devices — MitraClip and PASCAL — that doctors can insert through a catheter (a thin tube) to repair the valve without open-heart surgery. The study wants to find out which device works better for patients whose valve problems are more complicated.
When the mitral valve leaks badly, it can lead to heart failure and serious symptoms. Both devices work well in straightforward cases, but doctors aren't sure which one is safer and more effective for patients with more complex valve anatomy. This trial will help answer that question.
You likely qualify if…
You likely don't qualify if…
If you qualify and enroll, your heart team will decide whether you receive the MitraClip or PASCAL device based on your individual anatomy and needs. You will undergo a catheter-based procedure where doctors guide one of these devices through a tube inserted into a blood vessel to repair your leaky valve. You will be followed up afterward to see how well the device works for you and how you recover.
AI-generated summary from trial data · Jul 16, 2026 · Not medical advice
Germany
Sponsor
LMU Klinikum
Enrollment target
~180 participants
Started
April 2024
Primary completion
April 2027
Age range
18 Years and older
Last updated on clinicaltrials.gov in October 2024.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Jörg Hausleiter, Prof. Dr.
LMU Klinikum
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.