Plain-English translation of NCT06636357 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether nitrous oxide, a gas you breathe in, can quickly reduce severe suicidal thoughts. Researchers want to see if this treatment works faster than current options and to understand how it helps the brain. The study will give some people the active treatment and others a placebo (inactive gas) to compare results fairly.
When someone is having severe suicidal thoughts, they need help that works quickly—existing treatments can take weeks or months to work. This research aims to find out if this medication could provide faster relief during a mental health crisis.
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You will visit the study center on day 1, where you'll breathe in either the active treatment gas or placebo for 45 minutes while researchers monitor you—neither you nor the raters will know which one you're getting. You'll return one week later (day 8) for a second 45-minute breathing session, and this time you'll receive the active treatment if you didn't get it the first time. Throughout the study, researchers will collect blood and hair samples and perform brain wave recordings (EEG) to understand how the treatment works.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
Switzerland