Plain-English translation of NCT06636812 on ClinicalTrials.gov โ ยท Source last updated ยท Translation generated ยท How we translate trials
Phase 1 โ Testing in a small group (usually 20โ80 people) to find a safe dose and watch for side effects.
Researchers want to understand how a medication called losartan affects the way teenagers' brains process emotions and learn from fearful situations. Losartan is a blood pressure drug that has shown promise in adults for improving how the brain handles fear and anxiety. This study will give healthy teenagers a single dose of losartan or a placebo, then measure how well they complete emotion-related tasks on a computer.
Teenagers are at higher risk for developing anxiety disorders than other age groups, and they often don't respond as well to standard anxiety treatments like exposure therapy. Early research suggests this medication may help improve the brain's ability to reduce fear and anxiety, which could eventually lead to better treatments for anxious teenagers.
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You will visit the research site in Oxford once. After completing some screening tests and giving informed consent, you'll take either the medication or a placebo capsule. One hour later, when the medication reaches its peak level in your bloodstream, you'll complete a series of computerized tasks designed to measure how you process emotional information and learn from emotional situations. The entire visit will take a few hours, and researchers will monitor your safety throughout.
AI-generated summary from trial data ยท Jun 23, 2026 ยท Not medical advice
United Kingdom
Phase
Safety & dosing
Sponsor
University of Oxford
Collaborators
National Institute for Health Research, United Kingdom
Enrollment target
~60 participants
Started
March 2024
Primary completion
December 2025
This trial's estimated completion date has passed โ the record may not be fully up to date.
Age range
16 Years โ 20 Years
Last updated on clinicaltrials.gov in June 2025.
Reach out to the team running this trial. Response times vary โ some teams are faster than others.
Central contact
Andrea Reinecke, PhD
University of Oxford
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first โ no email needed to get started.