Plain-English translation of NCT06640309 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Rheumatoid Arthritis research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether nicotinamide, a form of vitamin B3, can help improve symptoms in people with rheumatoid arthritis. You would take the medication daily for three months along with your regular arthritis treatments. Researchers will measure whether this medication reduces joint pain, swelling, and blood markers of inflammation.
Rheumatoid arthritis is a serious condition that causes painful joint inflammation, and many patients still suffer even while taking standard treatments. This study explores whether this medication might provide additional benefit by calming the body's inflammatory response.
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You would visit the clinic at the start of the study and again after three months. Half the participants will receive a daily 1000mg in addition to their regular arthritis medications, while the other half will continue with their usual treatment only. At both visits, the research team will examine your joints, take blood samples to measure inflammation markers, and ask you about your symptoms and quality of life.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
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