Plain-English translation of NCT06640582 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.
This trial is testing a combination approach to treat advanced brain cancers like gliomas and meningiomas. Doctors will extract immune cells (called lymphocytes) directly from your tumor, grow many more of them in the laboratory, and then put them back into your body along with , an immunotherapy medication that helps these cells fight cancer more effectively.
Advanced brain cancers are very difficult to treat, and many patients run out of standard treatment options. This trial exists because early results from using this same approach in other cancers (like melanoma) have been promising, and researchers hope it could work for brain cancers too.
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You will have a surgical procedure to collect tumor cells for growing your immune cells in the laboratory. Then you'll receive preparation medications followed by an infusion of your expanded immune cells and the immunotherapy medication. You'll stay in the hospital during this intensive phase and then receive additional doses of the immunotherapy medication over several months, with regular follow-up visits to monitor how well the treatment is working and check for side effects.
AI-generated summary from trial data · Jul 6, 2026 · Not medical advice
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