Plain-English translation of NCT06643845 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether a comprehensive medical approach—combining physical therapy, weight loss, joint injections, pain medications, and careful shared decision-making with your doctors—can delay or prevent the need for knee replacement surgery. The study includes 1,000 patients with severe knee arthritis who have been recommended for surgery, to see if trying all available medical options first can postpone or eliminate the need for that operation.
Many patients are rushed to surgery without trying all available medical treatments first. Recent research shows that a complete course of medical care can work well and may prevent many unnecessary surgeries, while also helping manage related health conditions like diabetes and heart disease. This trial aims to prove that a thoughtful, team-based approach to treatment can delay surgery for most patients.
You likely qualify if…
You likely don't qualify if…
If you join the medical care group, you will work with rheumatologists to review all your current treatments and develop a personalized plan—which may include physical therapy sessions, weight loss support, special shoe inserts, joint injections, and various pain medications. You will receive personalized exercise videos and motivational support to help you stick with the program at home. The other group proceeds directly to knee replacement surgery as originally planned, so you will be randomly assigned to one approach or the other.
AI-generated summary from trial data · Jun 30, 2026 · Not medical advice
France