Plain-English translation of NCT06646809 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Colorectal Cancer research guide →Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
Surgery for colorectal cancer triggers an inflammatory response in the body, which can sometimes become too intense and lead to serious complications like infection or slow healing. This trial tests whether a supplement called AKG (alpha-ketoglutarate) taken once daily can calm this excessive inflammation and help patients recover better. The study focuses on older patients, who are more likely to have this overactive response.
Older patients undergoing colorectal cancer surgery often develop dangerous complications from excessive inflammation after their operation, including infections and poor wound healing. Current anti-inflammatory treatments have mixed results and can carry their own risks, so researchers are testing whether this medication offers a safer way to reduce these complications and speed recovery.
Before your scheduled colorectal cancer surgery, the research team will measure inflammation markers in your blood to see how your body responds to surgical stress. Based on these results, you will either receive standard care alone, or standard care plus a daily tablet of AKG or a placebo (dummy pill) for a period after surgery. The study tracks how well you recover, including any complications, hospital stay length, and how you feel during the healing process.
AI-generated summary from trial data · Jul 21, 2026 · Not medical advice
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