Plain-English translation of NCT06649058 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This is a research study for people with cancer that has spread to the brain. You would receive systemic therapy (a cancer medication given by mouth or vein) as your first treatment. Depending on how your tumors respond, you may then be randomly assigned to receive stereotactic radiosurgery—a precise, focused radiation treatment—or continued observation. The study is testing whether the timing and extent of radiation therapy improves how long patients stay without brain tumor progression.
Doctors currently disagree on the best way to treat brain metastases: should radiation be used right away, only if tumors grow after medication, or not at all? This trial aims to find out which approach works best for patients whose tumors respond well or stay stable with medication alone.
You likely qualify if…
You likely don't qualify if…
You would start with systemic therapy (cancer medication) as your first treatment and have MRI scans to check how your brain tumors respond. After a few months, if your tumors have shrunk, stayed the same, or disappeared, you may be randomly assigned to either receive stereotactic radiosurgery or continue observation with regular scans. If your tumors grow despite medication, you would be randomly assigned to receive radiation to either just the growing tumors or all remaining tumors. Throughout the study, you would have regular clinic visits, brain imaging, and possibly tests of your memory and thinking. The study also tracks any side effects and how well you do over time.
AI-generated summary from trial data · Jun 28, 2026 · Not medical advice
United States