Receive an experimental immune cell treatment for relapsed or refractory leukemia

Recruiting

What is this trial?

This trial is testing CD19 CAR-T cells, a personalized immune cell therapy designed to help your body's immune system fight back against certain types of leukemia that have relapsed or become resistant to standard chemotherapy. Researchers have seen promising early results in a small number of patients with this type of cancer, so they want to carefully study how safe this treatment is and whether it works. In this study, your own immune cells would be collected, modified in a laboratory to recognize and attack cancer cells, and then infused back into your body.

Standard chemotherapy and other treatments don't work well enough for many patients whose leukemia has come back or stopped responding to initial treatment, and new options are urgently needed. Early reports suggest this personalized cell therapy might help some patients achieve remission when other treatments have failed.

Do you qualify?

You likely qualify if…

you are 18 years of age or older
you have been diagnosed with acute myeloid leukemia (AML) that is relapsed, refractory (not responding), or has returned after a bone marrow transplant
your cancer cells express a protein called CD19 that can be detected by flow cytometry testing
you have an adequate life expectancy of more than 2 months based on your doctor's assessment
your body is strong enough to tolerate this treatment, as shown by acceptable kidney, heart, liver, and lung function tests

You likely don't qualify if…

you have cancer that has spread to your brain or central nervous system
you are pregnant or breastfeeding, or unwilling to use effective birth control for one year after treatment
you have serious heart, lung, liver, or kidney problems that are not adequately controlled
you have not fully recovered from severe side effects of previous cancer treatments

What participation looks like

You will undergo screening tests including blood work, heart and brain imaging, and a lung function test to make sure you are healthy enough for treatment. If you qualify, your immune cells will be collected through a procedure called leukapheresis, sent to a laboratory to be modified, and then returned to you for infusion into your bloodstream. You will then be closely monitored in the hospital and through follow-up visits for side effects and to see how well the treatment is working.

Testing a new immune cell therapy for hard-to-treat blood cancer

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)