Plain-English translation of NCT06649305 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This research study is testing two advanced imaging technologies — near-infrared spectroscopy and optical coherence tomography — to better identify dangerous plaques in the coronary arteries (the blood vessels that supply the heart) of people with diabetes. These imaging tools work together to create detailed pictures of artery walls and help doctors spot plaques that are at highest risk of rupturing and causing a heart attack. The study will help develop better ways to predict which patients are most at risk and what preventive treatments might help.
People with diabetes are at higher risk of heart disease and heart attacks caused by rupture of dangerous plaques inside coronary arteries. Currently, doctors don't have a reliable way to identify which plaques are most dangerous before they cause a heart attack. This study aims to develop a new measurement method that can accurately spot vulnerable plaques early, so doctors can prevent heart attacks and deaths before they happen.
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You will undergo specialized heart imaging tests using two advanced scanning technologies to examine your coronary arteries in detail. The imaging procedure takes place during a cardiac catheterization (a procedure where a small tube is guided into your heart's blood vessels). The study team will use the imaging information to evaluate your plaques and identify which ones pose the highest risk. You may need follow-up visits to track your health outcomes over time and check how well the new imaging method predicts your future heart health.
AI-generated summary from trial data · Jun 22, 2026 · Not medical advice
China
Sponsor
Shanghai Zhongshan Hospital
Enrollment target
~1,516 participants
Started
October 2024
Primary completion
July 2027
Age range
18 Years and older
Last updated on clinicaltrials.gov in February 2026.
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Central contact
Chenguang Li, Doctor
Shanghai Zhongshan Hospital
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