Plain-English translation of NCT06651697 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
Radiation therapy is a common treatment for cancers in the pelvis (bladder, colon, gynecologic organs, and related areas). Doctors have traditionally asked patients to have a full bladder during treatment to move other organs out of the way, but this study is testing whether keeping the bladder empty might work just as well or better. Researchers want to find out which approach reduces side effects and gives the best results.
Currently, doctors don't have strong scientific evidence about which bladder approach—full or empty—is truly best for pelvic radiation therapy. A full bladder can vary from day to day, which may affect how radiation is delivered. This study exists to compare both methods fairly and help doctors decide which is safest and most effective for future patients.
You likely qualify if…
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You will be randomly assigned to either the full-bladder or empty-bladder group. At your planning appointment (called CT simulation), you'll follow your assigned bladder protocol while imaging is done to map out your radiation treatment. Then, during your course of radiation therapy, you'll continue following the same protocol at each treatment session. The study team will monitor you throughout treatment to track any side effects and how well the radiation is working.
AI-generated summary from trial data · Jun 10, 2026 · Not medical advice
United States
Phase
Large-scale testing
Sponsor
University of California, San Diego
Enrollment target
~300 participants
Started
November 2024
Primary completion
April 2028
Age range
18 Years and older
Last updated on clinicaltrials.gov in February 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Tyler Seibert, MD, PhD
University of California, San Diego
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.