Plain-English translation of NCT06656416 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This study is testing a new medication called to see if it can help reduce depression in people with bipolar disorder. You would take this medication in addition to your current mood-stabilizing medications. The trial will compare to a placebo (inactive pill) to see which works better at easing depressive symptoms.
Depression is a significant problem for people with bipolar disorder, even when they're taking other medications to manage their mood. Researchers want to find out whether this new treatment can help fill that gap and provide better relief from depression symptoms.
You likely qualify if…
You likely don't qualify if…
The trial has two phases lasting about 13 weeks total. First, you'll enter a 6-week double-blind phase where you'll take either or a placebo pill twice daily alongside your regular medications—neither you nor the study team will know which one you're getting. Then, if you qualify, you'll enter a 7-week open-label phase where you'll know you're taking and continue taking it twice daily. Throughout the trial, you'll have regular study visits to check how you're doing and assess your mood symptoms.
AI-generated summary from trial data · Jun 11, 2026 · Not medical advice
United States