Plain-English translation of NCT06660225 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study is testing a surgical procedure called deep brain stimulation (DBS) for people with severe obsessive-compulsive disorder (OCD) that has not improved despite trying medications and therapy. Researchers will implant a small device in your brain that sends mild electrical signals to help reduce OCD symptoms. The goal is to understand both whether this treatment works and how it affects the brain's activity related to OCD.
OCD can be very disabling for some people, even after trying multiple medications and therapy approaches. This trial exists because this treatment offers hope for people with severe, resistant OCD who have few other options, and it could help researchers better understand how OCD develops in the brain.
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You would undergo brain surgery to have the stimulation device implanted, then participate in a 16-week comparison where half of participants start with the device turned off and half start with it turned on—after 4 months, groups switch. You'll have regular psychiatric evaluations every two to three weeks during the first phase, then every six weeks after that, along with brain activity recordings. After this comparison phase ends, everyone receives continuous stimulation therapy for the long term, with ongoing check-ins to monitor your symptoms and any side effects.
AI-generated summary from trial data · Jun 20, 2026 · Not medical advice
United States