Plain-English translation of NCT06660407 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether a specialized type of radiation called grid radiation therapy, when combined with immunotherapy (drugs that help your immune system fight cancer), can help people with advanced lung cancer whose cancer has continued to grow despite immunotherapy treatment. The grid radiation therapy delivers radiation in a specific pattern designed to work better alongside immune-boosting medications. Researchers want to see if this combination is safe and how well it works.
Some people with advanced lung cancer stop responding to immunotherapy alone, and their cancer continues to grow. This trial is exploring whether adding a specialized radiation therapy technique might help restart the body's immune response and control the cancer better.
You will receive a specialized radiation treatment (grid radiation) delivered in a single session on day 1, followed by additional palliative radiation over 5 sessions in the following days. You will continue taking your immunotherapy medications as prescribed by your doctor. Throughout the study, you will have CT scans and blood draws to monitor your progress and immune response, with clinic visits at 30 days after treatment, then every 8–12 weeks initially, and every 3 months for up to 5 years. You can have follow-up appointments either in person at Mayo Clinic or virtually with local blood work if that works better for you.
AI-generated summary from trial data · Jun 24, 2026 · Not medical advice
United States