Testing a Shock Wave Device for Hardened Heart Artery Blockages

Plain-English translation of NCT06662500 on ClinicalTrials.gov ↗ · Source last updated August 2026 · Translation generated August 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing the Shockwave Javelin Coronary IVL Catheter, a new device that delivers focused shock waves through a thin tube to break up calcium buildup in severely hardened heart arteries. The goal is to make these difficult blockages easier to treat and improve blood flow to the heart. This treatment is designed for patients with stable chest pain or those who have recovered from a heart attack.

Many patients with calcium-filled heart artery blockages are very difficult to treat with standard procedures. This medication aims to solve that problem by gently breaking up the calcium so doctors can more easily restore blood flow and prevent future heart problems.

Do you qualify?

You likely qualify if…

you are at least 18 years old
you have significant calcium buildup in a coronary artery that needs treatment
you have stable chest pain or have recovered from a recent heart attack
your heart's pumping strength (ejection fraction) is greater than 30%
you are expected to live longer than one year
you are able and willing to follow all study procedures and follow-up visits

You likely don't qualify if…

you have very high heart enzyme levels suggesting a recent or ongoing heart attack
you need emergency heart treatment right away
you have severely weakened heart function (ejection fraction of 30% or less)
you have already been treated in the target coronary artery with a successful procedure

What participation looks like

If you qualify, you will come to one of the participating hospitals for a heart catheterization procedure where doctors will use the Shockwave Javelin catheter to treat your blocked artery. The procedure is similar to standard coronary interventions but includes the new shock wave technology. You will have follow-up visits and tests to monitor how well the treatment worked and how you're feeling over time.

AI-generated summary from trial data · Aug 17, 2026 · Not medical advice

Trial locations(34 sites)

United States

Scripps Health, La Jolla, California

University of California, San Francisco, San Francisco, California

South Denver Cardiology Associates, P.C, Littleton, Colorado

Hartford Hospital, Hartford, Connecticut

Medstar Washington Hospital Center, Washington D.C., District of Columbia