Recruiting

High-Oxygen Therapy to Protect the Heart After a Heart Attack

Plain-English translation of NCT06662890 on ClinicalTrials.gov ↗ · Source last updated February 2025 · Translation generated August 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

After a heart attack, the heart muscle can weaken and change shape over time, which doctors call remodeling. This trial is testing whether Supersaturated Oxygen (SSO2) therapy — a treatment that delivers extra-concentrated oxygen directly into the heart's blood vessels using a thin tube — can prevent or reduce this damage when given right after emergency angioplasty (the procedure that reopens blocked arteries during a heart attack).

Heart attacks cause damage that sometimes leads to long-term weakening of the heart. Researchers want to know if delivering extra oxygen to the heart tissue immediately after treatment can help it heal better and prevent future heart problems.

Do you qualify?

You likely qualify if…

you are at least 18 years old
you have just had an anterior heart attack and are being treated in the hospital within 6 hours of symptom onset
your blocked artery has been successfully reopened with a catheter procedure and blood flow is restored
the radial artery in your wrist can be used for the treatment

You likely don't qualify if…

you are pregnant
you are in cardiogenic shock (severe heart failure) or have severe complications from the heart attack
you have had major bleeding or major surgery in the past two months
you have a severe metal implant or severe claustrophobia that would prevent you from having an MRI scan
you cannot receive blood-thinning medications

What participation looks like

After your emergency heart attack treatment is complete, you will receive either the new high-oxygen therapy or a sham (fake) procedure through an artery catheter in your wrist. You will have blood tests, heart imaging scans (including an MRI), and health questionnaires during your hospital stay and follow-up visits. The study team may also review your medical records electronically over time to track your recovery and heart health.

AI-generated summary from trial data · Aug 15, 2026 · Not medical advice

Trial locations(1 site)

United Kingdom

Golden Jubilee National Hospital, Clydebank, Dunbartonshire

Key details

Sponsor

NHS National Waiting Times Centre Board

Collaborators

British Heart Foundation, Zoll Medical Corporation

Enrollment target

~56 participants

Started

October 2024

Primary completion

November 2028

Age range

18 Years and older

Last updated on clinicaltrials.gov in February 2025.

Contact the research team directly

Reach out to the team running this trial. Response times vary — some teams are faster than others.

Central contact

Colin Berry, BSc MBChB PhD

NHS National Waiting Times Centre Board

Interested in joining?

Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.