Plain-English translation of NCT06665113 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing a treatment called transcutaneous auricular vagus nerve stimulation (taVNS)—a non-invasive procedure where small electrodes placed on your ear deliver gentle electrical stimulation to a specific nerve. Researchers believe this stimulation, combined with your regular Parkinson's medications, might help protect your brain cells and slow disease progression in the early stages. You would receive daily 30-minute treatment sessions for about nine months.
Current Parkinson's medications help manage symptoms, but they don't stop the disease from progressing. This trial explores whether this medication might offer a way to protect brain cells and delay worsening of the disease in its earliest stages.
You likely qualify if…
You likely don't qualify if…
You would visit the research center at least 5 days per week for 270 consecutive days (about 9 months). During each visit, you would receive a 30-minute stimulation session where small electrodes on your ear deliver gentle electrical stimulation. Half of participants will receive real stimulation near a specific nerve in the ear, while the other half will receive sham stimulation on the earlobe—neither you nor the researchers will know which group you're in. Throughout the trial, you'll continue taking your regular Parkinson's medications and undergo periodic tests to measure any changes in your symptoms.
AI-generated summary from trial data · Jul 7, 2026 · Not medical advice
China
Sponsor
Kezhong Zhang
Enrollment target
~12 participants
Started
December 2024
Primary completion
June 2026
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
55 Years – 75 Years
Last updated on clinicaltrials.gov in January 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Kezhong Zhang, Professor
The First Affiliated Hospital with Nanjing Medical University
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.