Plain-English translation of NCT06665386 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Stroke research guide →Acute ischemic stroke happens when a blood clot blocks blood flow to the brain. Doctors can remove these clots using a procedure called endovascular thrombectomy. This study tests whether adding selective intra-arterial cooling infusion—a technique that cools the brain by infusing cold saline through the blood vessels—helps patients recover better when combined with the clot removal procedure.
Even after doctors successfully remove the blood clot, many stroke patients still have poor outcomes. Cooling the brain has shown promise in early studies as a way to protect brain tissue and slow stroke damage, so researchers want to understand if this treatment truly improves recovery when used together with clot removal.
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Participants in this study will receive either standard stroke treatment (best medical management plus clot removal) or the same treatment combined with cooling therapy through intra-arterial cold saline infusion. Both groups will have blood samples taken to identify biological markers that predict how well the treatment works. The trial involves comparing these two treatment approaches in approximately 258 patients across multiple medical centers to understand which patients benefit most from the cooling therapy.
AI-generated summary from trial data · Jul 13, 2026 · Not medical advice
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