Plain-English translation of NCT06666764 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This trial is testing normobaric hyperoxia — which means giving patients 100% oxygen through a mask or similar device — during the critical hours after an acute ischemic stroke while they are being transferred to a hospital for emergency clot-removal surgery. Researchers believe that flooding the brain with extra oxygen before the clot is removed may help protect brain tissue and improve long-term recovery. The study will compare patients who receive this oxygen treatment alongside standard care to those who receive standard care alone.
Even after successful clot-removal surgery, many stroke patients don't recover as well as doctors hope. This treatment is being tested because extra oxygen may help rescue brain tissue that is at risk of dying before blood flow is restored, potentially reducing the damage from stroke.
You likely qualify if…
You likely don't qualify if…
If you qualify and enroll, you will be randomly assigned to either receive high-concentration oxygen or standard care during your transfer to the stroke surgery hospital. You will then proceed with your standard stroke treatment and emergency clot-removal surgery as planned. The study team will follow your recovery and check in with you at 90 days after your stroke to see how well you have recovered. The oxygen treatment itself is non-invasive and simply involves breathing from a mask.
AI-generated summary from trial data · Jul 4, 2026 · Not medical advice
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