Plain-English translation of NCT06668571 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Depressive Disorder, Treatment-Resistant research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether —a medication that works differently than standard antidepressants—can help people with severe depression that hasn't responded to at least two other treatments. Half of the participants will receive a single infusion, while the other half will receive a placebo (salt water), and researchers will measure changes in depression symptoms and brain chemistry to understand how the medication works.
Many people with depression don't get better even after trying multiple antidepressant medications, leaving them with few options. This study aims to understand whether this medication could offer hope for people with treatment-resistant depression and to learn more about how it affects brain chemistry.
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You will come to the clinic for a single visit where you'll receive either the infusion or placebo (salt water) intravenously over 40 minutes while inside an MRI scanner so researchers can measure brain activity and chemistry. Blood samples will be taken to measure chemical markers in your body. After this initial visit, you'll have the option to receive an additional open-label infusion if you wish. The study will track your depression symptoms using standardized rating scales to see whether the treatment helped.
AI-generated summary from trial data · Jul 5, 2026 · Not medical advice
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