Plain-English translation of NCT06670053 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers want to understand how affects the developing brain and whether it influences headaches in transmasculine youth. This study will compare two groups: young people who have been taking puberty blockers before starting , and those who haven't. By taking brain images and tracking headaches over time, the team hopes to learn more about safe hormone therapy for transgender youth.
While therapy is an important part of gender-affirming care, doctors don't yet fully understand how this treatment affects brain development or headache patterns in young people. This study aims to fill that gap and help ensure this medication is used safely.
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You would visit the research center for morning appointments to capture your natural hormone levels at their peak. During your visits, you'll have basic measurements taken (like weight and height), complete several short questionnaires about anxiety, mood, and any headaches you've experienced, and have a brain imaging scan (MRI). You'll also keep a simple daily headache diary—brief on days without headaches, more detailed on days when you do have one. The study team will review your medical records for relevant health information throughout your participation.
AI-generated summary from trial data · Jun 1, 2026 · Not medical advice
United States