Recruiting

Testing a new medication to prevent heart failure in people with diabetes

Plain-English translation of NCT06677060 on ClinicalTrials.gov ↗ · Source last updated July 2026 · Translation generated June 2026 · How we translate trials

What is this trial?

This study is testing a new medication called baxdrostat to see if it can prevent heart failure when taken together with dapagliflozin, a medication you may already be taking for diabetes. About half of participants will receive the new medication plus the diabetes drug, and half will receive just the diabetes drug with a placebo (dummy pill). The study will track whether the medication helps reduce serious heart problems over time.

Heart failure is a major risk for people with diabetes and heart disease, and current treatments don't prevent it well enough. Researchers believe this medication may offer extra protection by working through a different pathway in the body.

Do you qualify?

You likely qualify if…

you are at least 40 years old
you have been diagnosed with type 2 diabetes that requires treatment
you have established cardiovascular disease (such as a past heart attack, stroke, or artery disease)
you have high blood pressure with a systolic reading of at least 130 mmHg
you have at least one additional heart failure risk factor, such as being 70 or older, reduced kidney function, or a history of atrial fibrillation

You likely don't qualify if…

you have previously been diagnosed with and treated for heart failure
you have very low kidney function (eGFR less than 30)
you have high potassium levels in your blood (5.5 mmol/L or higher) within the past 3 months
you had a heart attack, stroke, or major heart surgery within the past 3 months
you have severe liver disease or a history of adrenal gland failure

What participation looks like

You will have a screening visit to confirm you qualify, followed by a run-in period of up to 6 weeks taking the diabetes medication if you're not already on it. Once enrolled, you will be randomly assigned to either the new medication plus the diabetes drug or a placebo plus the diabetes drug. You will visit the clinic about 5 times in the first 8 months, then every 4 months after that. The study will continue until a certain number of heart-related events have occurred, which typically takes several years; you will have blood tests, blood pressure checks, and be asked about any health changes during this time.

Testing a new medication to prevent heart failure in people with diabetes

What is this trial?

Do you qualify?

What participation looks like

Trial locations(953 sites)