Testing a three-part inhaler for poorly controlled asthma

Plain-English translation of NCT06678191 on ClinicalTrials.gov ↗ · Source last updated November 2024 · Translation generated June 2026 · How we translate trials

What is this trial?

This trial tests Trimbow 172/5/9, a combination inhaler that contains three medications in one device. The study will follow 800 adults with severe asthma for six months to see whether switching to this medication improves asthma symptoms and control. Researchers will collect information during regular doctor visits at asthma clinics across Hungary.

Many people with asthma continue to have symptoms and flare-ups even when taking two or three separate asthma medications. This study wants to understand whether this medication — which combines three treatments into one inhaler — might work better and make it easier for people to use their asthma treatment correctly.

Do you qualify?

You likely qualify if…

you are 18 years or older and have been diagnosed with asthma for at least 3 years
your asthma is not well controlled despite taking a long-acting bronchodilator plus a high-dose steroid inhaler (or three-medication therapy) for at least 3 months
you have had at least one asthma flare-up requiring oral or intravenous steroids in the past 12 months
your doctor has recently decided to switch you to this three-part inhaler (within the past week or on the day you join)
you are willing to give written consent to participate and can attend regular clinic visits

You likely don't qualify if…

you were hospitalized for an asthma flare-up in the past 4 weeks
you are taking high-dose oral steroids daily (more than 5 mg prednisolone or 4 mg methylprednisolone)
you are using continuous oxygen therapy
you have had cancer or active tuberculosis in the past 5 years
you have used biologic asthma medications in the past 12 months

What participation looks like

You will use the three-part inhaler (Trimbow) as prescribed by your doctor — taking two puffs twice daily — and continue your regular visits to the asthma clinic. Over 6 months, your doctor will track how well your asthma symptoms are controlled using a simple questionnaire called the ACT score. You won't need extra hospital visits or extra tests beyond what your doctor would normally do to manage your asthma.

AI-generated summary from trial data · Jun 2, 2026 · Not medical advice

Trial locations(45 sites)

Hungary

Békés Megyei Központi Kórház, 2. Tüdőgyógyászat szakrendelés - 1. rendelés, Békéscsaba

Kispesti Egészségügyi Intézet Tüdőgondozó, Ernyőképszűrő állomás, Budapest

Országos Korányi Pulmonológiai Intézet (OKPI), Budapest

Semmelweis Egyetem, Általános Orvostudományi Kar, Pulmonológiai Klinika, Budapest

Szent Kristóf Szakrendelő XI. Kerületi Tüdőgondozó, Budapest