Plain-English translation of NCT06679816 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This trial is testing whether hydrocortisone—a steroid hormone replacement—can prevent serious hormone deficiencies after surgery for large pituitary tumors. During and after your surgery, you would receive either the medication or a placebo (a dummy treatment that looks identical but contains no active drug) for about two weeks. Researchers want to know if this medication reduces the chance of developing adrenal insufficiency, a condition where your body doesn't produce enough cortisol.
Large pituitary tumors can affect your body's natural hormone production, and surgery to remove them sometimes makes this problem worse. Doctors aren't yet sure whether giving this medication immediately after surgery prevents dangerous hormone imbalances, so this trial will help answer that question.
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You would receive either hydrocortisone or a placebo every day for 2 weeks, either as a pill or through an IV infusion, starting around the time of your pituitary surgery. You'll visit the clinic three months after your surgery for follow-up checkups and blood tests to see how you're doing. Throughout this time, you'll keep a symptom diary to track how you're feeling, which helps researchers understand whether the treatment is working.
AI-generated summary from trial data · Jun 4, 2026 · Not medical advice
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