Plain-English translation of NCT06681246 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Obesity research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study is exploring whether a 10-day course of Augmentin (amoxicillin and clavulanate) can help prevent weight regain after you've successfully lost weight through a personalized diet plan. Researchers believe your gut bacteria—your microbiome—may play a role in weight regain, and this medication may help protect against that. Half of participants will receive the actual medication, and half will receive a placebo (a pill with no active ingredient), so researchers can fairly compare what works.
Many people struggle to keep weight off after dieting, even when they've worked hard to lose it. This trial is investigating whether changing your gut bacteria with this medication might help your body maintain weight loss better over time.
You likely qualify if…
You likely don't qualify if…
You'll be in the study for up to one year. First, you'll have a baseline week of screening and sample collection (stool and blood samples). Then you'll follow a personalized weight-loss diet with check-in meetings twice a month for three months. After that, you'll take either the medication or placebo for 10 days. Finally, you'll have follow-up visits once a month for 3 months, then every 3 months for the remaining time, so researchers can track whether you're keeping the weight off.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
Israel