Plain-English translation of NCT06682481 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers are looking for a new blood test marker called 1,5-AG that may help them understand how well the pancreas is working in teenagers with obesity. This study will measure this marker in 50 children ages 12–16 and follow them over two years to see if it's a reliable way to track pancreas health. The goal is to develop a better tool for detecting early pancreas problems before diabetes develops.
Many obese teenagers are at risk for type 2 diabetes, but doctors don't have a good early warning sign to catch pancreas problems before they get serious. This trial is testing whether a simple blood marker could give doctors an earlier heads-up about pancreas damage, so they can help teens before diabetes sets in.
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You will visit the hospital twice over two years. At each visit, you'll have blood drawn and take an oral glucose tolerance test (a standard test where you drink a sweet drink and have your blood sugar checked afterward). The researchers will measure the 1,5-AG level in your blood and compare it to how your pancreas is working. The whole process takes a few hours per visit.
AI-generated summary from trial data · Jun 12, 2026 · Not medical advice
Switzerland
Collaborators
University of Geneva, Switzerland
Enrollment target
~50 participants
Started
November 2024
Primary completion
December 2028
Age range
12 Years – 16 Years
Last updated on clinicaltrials.gov in May 2026.
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Central contact
Philippe Klee
Philippe Klee, MD-PhD
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