Plain-English translation of NCT06683378 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Parkinson's Disease research guide →Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This is an early-stage research study testing whether autologous peripheral nerve tissue implanted into the brain during deep brain stimulation surgery can help treat Parkinson's disease. The researchers will place your own nerve tissue into one of two brain regions—either the substantia nigra or the nucleus basalis of Meynert—to see if it can support brain repair and improve your thinking, movement, and quality of life. You'll be monitored closely over two years to see how well this treatment works and whether it's safe.
Many people with Parkinson's disease struggle with thinking problems and movement symptoms that don't fully respond to standard treatments. This study explores whether implanting your own nerve tissue—which may help repair damaged brain areas—could offer additional relief when combined with deep brain stimulation surgery.
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If you join this study, you will undergo surgery where doctors will harvest a small piece of nerve tissue from your leg and implant it into your brain during your scheduled deep brain stimulation procedure. You will then return for follow-up visits at 2 weeks, 6 months, 12 months, and 24 months after surgery to have your thinking, movement, daily activities, and quality of life assessed through tests and interviews. The entire study commitment lasts about 2 years from your surgery date.
AI-generated summary from trial data · Sep 3, 2026 · Not medical advice
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