Plain-English translation of NCT06687694 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers want to understand why psychosis happens and why antipsychotic medications work differently for different people. This study collects blood samples — and optionally spinal fluid — from people experiencing psychosis symptoms who are starting or switching antipsychotic medication, plus healthy volunteers for comparison. The goal is to find biological markers (signs in your blood) that could help doctors predict who will respond well to treatment and personalize care.
Right now, doctors can't easily predict which patients will benefit from which antipsychotic medication. By studying how the immune system changes during treatment, researchers hope to discover new ways to diagnose psychosis earlier, choose the right medication faster, and develop new immune-based treatments in the future.
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You would have two main visits: one at the start of your new medication (or at enrollment if you're a control participant) and another visit 4 weeks later. At each visit, researchers will take a blood sample and ask you questions about your symptoms. Some participants may be asked to provide an optional spinal fluid sample through a lumbar puncture procedure. The whole process takes place over about a month.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
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